By Megan Brooks

Eliezer Masliah, MD, director of the neuroscience division at the National Institute on Aging (NIA), has been "relieved of his position" following an investigation by the National Institutes of Health (NIH) that turned up research misconduct, the NIH said in a statement.

The misconduct involved "falsification and/or fabrication involving reuse and relabel of figure panels representing different experimental results in two publications," the NIH said.

The agency said it will notify the two journals of its findings so that appropriate action can be taken.

The NIH reportedly launched its probe into potential research misconduct in May 2023 after it received allegations from the Health and Human Service (HHS) Office of Research Integrity (ORI) that same month.

The investigation phase began in December 2023 and concluded on September 15, 2024. The institute subsequently notified HHS ORI of its findings.

Masliah joined the NIH in the summer of 2016 as director of the Division of Neuroscience at the NIA and an NIH intramural researcher investigating synaptic damage in neurodegenerative disorders, publishing "numerous" papers, the NIH said.

Given the findings of their investigation, the NIH said, Masliah is no longer serving as director of NIA's Division of Neuroscience.

NIA deputy director Amy Kelley, MD, is now acting director of NIA's neuroscience division.

Consistent with NIH policies and procedures, any allegations involving Masliah's NIH-supported extramural research prior to joining NIH would be referred to HHS ORI, the NIH said.

The NIH announcement came on the same day that investigative piece was published, suggesting that Masliah may have fabricated or falsified images or other information in far more than the two studies NIH cited.

According to the article, "scores" of Masliah's lab studies conducted at the NIA and the University of California San Diego are "riddled with apparently falsified Western blots — images used to show the presence of proteins — and micrographs of brain tissue. Numerous images seem to have been inappropriately reused within and across papers, sometimes published years apart in different journals, describing divergent experimental conditions."

The article noted that a neuroscientist and forensic analysts had produced a "300-page dossier revealing a steady stream of suspect images between 1997 and 2023 in 132 of his published research papers."

They concluded that this "pattern of anomalous data raises a credible concern for research misconduct and calls into question a remarkably large body of scientific work," the article stated.

In a statement, UC San Diego said it "received allegations of research misconduct from the Health and Human Services (HHS) Office of Research Integrity (ORI) against Eliezer Masliah, MD. Masliah was employed by the university from 1990 to 2016.

"UC San Diego is committed to the highest ethical and legal standards in the conduct of research and we take allegations of research misconduct very seriously. Our Office of Research Compliance and Integrity addresses all allegations in accordance with university policy and procedures."